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Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment.

Neurobiol Aging.. 2014-06; 
David R. Whitfield, PhD, Julie Vallortigara, PhD, Amani Alghamdi, MSc, David Howlett, PhD, Tibor HortobÁgyi, MD PhD, Mary Johnson, BA, Johannes Attems, MD, Stephen Newhouse, PhD, Clive Ballard, MD, Alan J. Thomas, PhD, John T. O'Brien, DM, Dag Aarsland, MD, Paul T. Francis, PhD1. Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College London, UK. SE1 1UL.
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摘要

The loss of zinc transporter 3 (ZnT3) has been implicated in age-related cognitive decline in mice and the protein has been associated with plaques. We investigated the levels of ZnT3 and PSD95, a marker of the post-synaptic terminal, in people with Parkinson's disease dementia (PDD n=31), dementia with Lewy bodies (DLB n=44), Alzheimer's disease (AD n=16) and controls (n=24), using semi-quantitative western blotting and immunohistochemistry in three cortical regions. Standardized cognitive assessments during life and semi-quantitative scoring of Aβ, tau and α-synuclein at post-mortem were used to investigate the relationship between ZnT3 and PSD95, cognition and pathology.

关键词

Alzheimer's disease; Dementia with Lewy bodies; Parkinson's disease with dementia; synaptic dysfunction; zinc; beta amyloid; tau; cognitive impairment