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Autocrine IL-8 Promotes F-actin Polymerization and mediate mesenchymal transition via ELMO1-NF-κB-Snail signalling in glioma.

Cancer Biol Ther.. 2015-04;  :1-14
Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Department of Pathology; Weifang Medical University; Weifang, PR China
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摘要

Glioma is the most common form of primary malignant brain cancers. Tumor cell invasiveness is a critical challenge in the clinical management of glioma patients. The invasive biological feature of glioma cell is stimulated by both autocrine and paracrine factors including chemokine IL-8. In this study, we report that the production of IL-8 is higher in glioma tissues and cells than adjacent nontumor tissues (ANT) and normal glial cells. Autocrine IL-8 can increase the invasive ability of glioma cells by binding to CXCR1. In addition, high expression of IL-8 indicates poor prognosis of glioma patients. Furthermore, IL-8 is capable of modulating cell migration and invasion by regulating the activation of RAC1 whi... More

关键词

ANT, adjacent nontumor tissues; CM, conditioned medium; CXCR1, chemokine (C-X-C motif) receptor 1; CXCR2, chemokine (C-X-C motif) receptor 2; Dock180, dedicator of cytokinesis; ELMO1; ELMO1, engulfment and cell motility 1; EMT, epithelial-mesenchymal transition; GBM, glioblastoma; GEFs, guanine nucleotide exchange factors; GPCR, G protein coupled receptor; IDH1, isocitrate dehydrogenase 1; IHS, immunohistochemical score; IL-8; IL-8, interleukin-8; MMP-2, matrix metalloproteinase-2; MMP-9, matri