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A Comparison of the Ability of Leu- and Pro-Oxytocin to Regulate Intracellular Ca and Ca-Activated K Channels at Human and Marmoset Oxytocin Receptors

Mol. Pharmacol.. 2019; 
PierceMarsha L, MehrotraSuneet, MustoeAaryn C, FrenchJeffrey A, MurrayThom
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Stable Cell Lines … Corresponding Author: Thomas F. Murray, Department of Pharmacology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68178, USA Phone: 402- 280-4076 … CHO-K1 cell lines were purchased from Genscript (M00195). Marmoset oxytocin … Get A Quote

摘要

The neurohypophyseal hormone oxytocin (OT) regulates biologic functions in both peripheral tissues and the central nervous system. In the central nervous system, OT influences social processes, including peer relationships, maternal-infant bonding, and affiliative social relationships. In mammals, the nonapeptide OT structure is highly conserved with leucine in the eighth position (Leu-OT). In marmosets (), a nonsynonymous nucleotide substitution in the gene codes for proline in the eighth residue position (Pro-OT). OT binds to its cognate G protein-coupled receptor (OTR) and exerts diverse effects, including stimulation (G) or inhibition (G) of adenylyl cyclase, stimulation of potassium channe... More

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