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Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5 Stem Cells via Inhibition of Wnt and Notch Signaling.

Cell Mol Gastroenterol Hepatol. 2019; 
ZhaJuan-Min,LiHua-Shan,LinQian,KuoWei-Ting,JiangZhi-Hui,TsaiPei-Yun,DingNing,WuJia,XuShao-Fang,WangYi-Tang,PanJian,ZhouXiu-Min,ChenKai,TaoMin,OdenwaldMatthew A,TamuraAtsushi,TsukitaSachiko,TurnerJerrold R,HeWe
Products/Services Used Details Operation
… mL). Blue symbols indicate enteroids cultured without IL22. Sources of IL22, from left to right, were GenScript Z03350, GenScript Z02197, R&D 582ML-010, R&D 582ML-010/CF, and PeproTech 201-22 (gold symbols). Each …

摘要

Epithelial regeneration is essential for homeostasis and repair of the mucosal barrier. In the context of infectious and immune-mediated intestinal disease, interleukin (IL) 22 is thought to augment these processes. We sought to define the mechanisms by which IL22 promotes mucosal healing.

关键词

Enteroid,Interleukin 22,Intestinal Stem Cell,Regeneration,Transit-Amplifying Cell,claudin-2,notch,tight junction