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Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations.

Cell Metab.. 2018; 
He Xia-Di,Gong Wei,Zhang Jia-Nong,Nie Ji,Yao Cui-Fang,Guo Fu-Shen,Lin Yan,Wu Xiao-Hui,Li Feng,Li Jie,Sun Wei-Cheng,Wang En-Duo,An Yan-Peng,Tang Hui-Ru,Yan Guo-Quan,Yang Peng-Yuan,Wei Yun,Mao Yun-Zi,Lin Peng-Cheng,Zhao Jian-Yuan,Xu Yanhui,Xu Wei,Zhao Shi
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摘要

Amino acids are known regulators of cellular signaling and physiology, but how they are sensed intracellularly is not fully understood. Herein, we report that each aminoacyl-tRNA synthetase (ARS) senses its cognate amino acid sufficiency through catalyzing the formation of lysine aminoacylation (K-AA) on its specific substrate proteins. At physiologic levels, amino acids promote ARSs bound to their substrates and form K-AAs on the ?-amine of lysines in their substrates by producing reactive aminoacyl adenylates. The K-AA marks can be removed by deacetylases, such as SIRT1 and SIRT3, employing the same mechanism as that involved in deacetylation. These dynamically regulated K-AAs transduce signals of t... More

关键词

amino acid sensing,deacetylase,deaminoacylation,lysine aminoacylation,tRNA synthet