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Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth.

Cancer Res. 2020; 
Qu YY,,, Zhao R, Zhang HL,, Zhou Q, Xu FJ,, Zhang X, Xu WH,, Shao N,, Zhou SX,, Dai B,, Zhu Y,, Shi GH,, Shen YJ,, Zhu YP,, Han CT,, Chang K,, Lin Y,,, Zang WD, Xu W,,, Ye DW,, Zhao SM,,, Zhao JY,,.
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Catalog Antibody … CAS#110187-42-3) were purchased from Cambridge Isotope Laboratories. Primary 6 antibodies used in this study include β-actin (Cat No. A00702, Genscript, Piscataway, 7 NJ, USA), α-ECHS1 (Cat No. H00001892-D01P, Abnova, Taipei City, Taiwan), 8 α-GATA3 (Cat No … Get A Quote

摘要

The tumorigenic role and underlying mechanisms of lipid accumulation, commonly observed in many cancers, remain insufficiently understood. In this study, we identified an AMP-activated protein kinase (AMPK)-GATA-binding protein 3 (GATA3)-enoyl-CoA hydratase short-chain 1 (ECHS1) pathway that induces lipid accumulation and promotes cell proliferation in clear cell renal cell carcinoma (ccRCC). Decreased expression of ECHS1, which is responsible for inactivation of fatty acid (FA) oxidation and activation of de novo FA synthesis, positively associated with ccRCC progression and predicted poor patient survival. Mechanistically, ECHS1 downregulation induced FA and branched-chain amino acid (BCAA) accumulation, whic... More

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