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The noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: implications for development and Parkinson's disease

ScienceDirect. 2020; 
Oum KaltoumHassaniaVladimir V.RymaraKhanh Q.NguyenaLiaHuoaJean-FrançoisCloutieraFreda D.MillerbAbbas F.Sadikota
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Recombinant Proteins Santa Cruz, SC-546), total TrkB (1:1000, rabbit; Cell Signaling Technologies, 4603), phosphorylated TrkB (1:1000, rabbit; Epitomics, 2149), and β-actin (1:6000, mouse; GenScript, A00702). Get A Quote

摘要

The cause of midbrain dopaminergic (mDA) neuron loss in sporadic Parkinson's disease (PD) is multifactorial, involving cell autonomous factors, cell-cell interactions, and the effects of environmental toxins. Early loss of neurons in the locus coeruleus (LC), the main source of ascending noradrenergic (NA) projections, is an important feature of PD and other neurodegenerative disorders. We hypothesized that NA afferents provide trophic support for vulnerable mDA neurons. We demonstrate that depriving mDA neurons of NA input increases postnatal apoptosis and decreases cell survival in young adult rodents, with relative sparing of calbindin-positive subpopulations known to be resistant to degeneration in PD. As a... More

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