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Blockage of NDUFB9‑SCD1 pathway inhibits adipogenesis

J Physiol Biochem. 2022-02; 
Shenglong Zhu, Jingwei Zhang, Wei Wang, Xuan Jiang, Yong Q Chen
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Recombinant Proteins The plasmids were prepared by GenScript Biotech...Fibroblast Growth Factor-basic (bFGF, GenScript Biotech Corporation, Z03016)...Epidermal Growth Factor (EGF, GenScript Biotech Corporation, Z02972) Get A Quote
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摘要

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with an increasing global prevalence associated with tremendous clinical, economic, and health-related quality-of-life burden. Currently, no effective pharmacological therapy is available for NAFLD. Adipogenesis process is accompanied by fat synthesis which may participate in the occurrence and development of NAFLD. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear and many potential therapeutic targets are yet to be discovered.In this study, the transcriptomics and lipidomics approaches were used to explore the functional genes regulating adipogenesis and the potential mechanism in OP9 cells and adip... More

关键词

Adipogenesis; NAFLD; Ndufb9; Scd1.