黄金城集团

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

DNA-protein cross-links between abasic DNA damage and mitochondrial transcription factor A (TFAM)

Nucleic Acids Res. 2022-12; 
Wenyan Xu , Jin Tang , Linlin Zhao
Products/Services Used Details Operation
Catalog Antibody The membrane was blocked using a 3% BSA solution for 1 h at 23◦C followed by incubation with 1/1000 diluted primary mouse anti-myc IgG antibody (GenScript, A00704-100) for myc-tagged UNG1 Get A Quote

摘要

In higher eukaryotic cells, mitochondria are essential organelles for energy production, metabolism, and signaling. Mitochondrial DNA (mtDNA) encodes 13 protein subunits for oxidative phosphorylation and a set of tRNAs and rRNAs. mtDNA damage, sourced from endogenous chemicals and environmental factors, contributes to mitochondrial genomic instability, which has been associated with various mitochondrial diseases. DNA-protein cross-links (DPCs) are deleterious DNA lesions that threaten genomic integrity. Although much has been learned about the formation and repair of DPCs in the nucleus, little is known about DPCs in mitochondria. Here, we present in vitro and in cellulo data to demonstrate the formation of DP... More

关键词