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Hsp40 proteins modulate humoral and cellular immune response in rheumatoid arthritis patients.

Cell Stress Chaperones.. 2010-09; 
Tukaj S, Kotlarz A, Jozwik A, Smolenska Z, Bryl E, Witkowski JM, Lipinska B. Department of Biochemistry, University of Gdansk, Kladki 24, 80-822 Gdansk, Poland.
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摘要

Recent research on the heat shock proteins (Hsps) in chronic inflammatory diseases indicates that Hsps may have disease-suppressive activities. Our aim was to characterize immune response directed to bacterial (DnaJ) and human Hsp40s in patients with rheumatoid arthritis (RA). We found elevated levels of anti-DnaJ, anti-Hdj2, and anti-Hdj3 (but not ant-Hdj1) serum antibodies in the RA patients (P < or = 0.001) compared to healthy controls. In peripheral blood mononuclear cells (PBMCs) culture, all tested Hsp40 proteins significantly inhibited the divisions of CD4+ and CD8+ T cells of the RA patients but not those of the controls. Both DnaJ and Hdj2 stimulated secretion of the main anti-inflammatory cytokine ... More

关键词

Heat shock proteins; Rheumatoid arthritis; Hsp4, DnaJ; E. coli