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LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway

iScience. 2023-10; 
Kai-Jie He, Jin-Bao Zhang, Jun-Yi Liu, Feng-Lun Zhao, Xiao-Yu Yao, Yu-Ting Tang, Jin-Ru Zhang, Xiao-Yu Cheng, Li-Fang Hu, Fen Wang, Chun-Feng Liu
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Molecular Biology Reagents … pronounced at a certain stage during the development of PD. … LAL endotoxin assay kit (L00350, GenScript, USA). The … different treatments were determined by ELISA in the control, … Get A Quote

摘要

Parkinson's disease (PD) is characterized by the irreversible loss of dopaminergic neurons and the accumulation of α-synuclein in Lewy bodies. The oligomeric α-synuclein (O-αS) is the most toxic form of α-synuclein species, and it has been reported to be a robust inflammatory mediator. Mutations in () are also genetically linked to PD and neuroinflammation. However, how O-αS and LRRK2 interact in glial cells remains unclear. Here, we reported that mutation, which is one of the most frequent causes of familial PD, enhanced the effects of O-αS on astrocytes both and . Meanwhile, inhibition of LRRK2 kinase activity could relieve the inflammatory effects of both and O-αS. We also demonstrated that nuclea... More

关键词

Biological sciences, Immunology, Molecular biology, Neuroscience