黄金城集团

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Polyoma Small T Antigen Interacts with YES-Associated Protein (YAP) to Regulate Cell Survival and Differentiation.

J Virol.. 2014-08; 
Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Hahn WC, Schaffhausen BS, Roberts TM. Departments of Cancer Biology and Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215.
Products/Services Used Details Operation

摘要

Murine polyomavirus small T antigen (PyST) regulates cell cycle, cell survival, apoptosis, differentiation and cooperates with middle T antigen (MT) to transform primary cells in vitro and in vivo. Like all polyoma virus T antigens, PyST functions largely via its interactions with host cell proteins. Here we show that PyST binds both Yes-associated proteins YAP1 and YAP2, integral parts of the Hippo signaling pathway, which is a subject of increasing interest in human cancer. The transcription factor TEAD, which is a known target of YAP, is also found in PyST complexes. PyST enhanced YAP association with protein phosphatase 2A (PP2A) leading to decreased YAP phosphorylation. PyST increased YAP levels by decreas... More

关键词