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Effect of GDNF on Morphology, Proliferation, and Phagocytic Activity of Rat Neonatal Cortex Isolated Microglia
BioNanoSci.2016-01;
Margarita Zhuravleva & Albert Rizvanov1 & Yana Mukhamedshina
Products/Services Used
Details
Operation
MOG 35-55 (myelin oligodendrocyte glycoprotein) and
βAP 25-35 (β-amyloid peptide) were obtained from
GenScript (USA), #RP10245 and RP10008-5, respectively
摘要
t Microglia are the main defenders of the central
nervous system and at the same time are involved in the
pathogenesis of various neurological disorders. Microglia
hyperactivity or phagocytic impairment exacerbates degenerative processes in nervous tissue leading to further
loss of function. A variety of factors and cytokines may
modify microglia function. In our study, it was shown
that glial cell line-derived neurotrophic factor (GDNF),
a well-known neuroprotective molecule, decreases
phagocytic activity of microglia in vitro model of spinal
cord injury. Recombinant adenovirus encoding GDNF
(Ad5-GDNF) transfected microglia have shown the same
effect and can be potentially used as a therapeutic agen... More
t Microglia are the main defenders of the central
nervous system and at the same time are involved in the
pathogenesis of various neurological disorders. Microglia
hyperactivity or phagocytic impairment exacerbates degenerative processes in nervous tissue leading to further
loss of function. A variety of factors and cytokines may
modify microglia function. In our study, it was shown
that glial cell line-derived neurotrophic factor (GDNF),
a well-known neuroprotective molecule, decreases
phagocytic activity of microglia in vitro model of spinal
cord injury. Recombinant adenovirus encoding GDNF
(Ad5-GDNF) transfected microglia have shown the same
effect and can be potentially used as a therapeutic agent
in case of neurotrauma due to its debris phagocytic and
GDNF-associated neuroprotective role.