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Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation.

Biochem. Pharmacol.. 2016; 
ZhengZu-Guo,ZhouYa-Ping,ZhangXin,ThuPyone Myat,XieZhi-Shen,LuChong,PangTao,XueBin,XuDa-Qian,ChenYan,ChenXiao-Wei,LiHui-Jun,XuXia
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Catalog Antibody … No. sc-12107) and anti-golgin245 (cat. No. sc-102565) antibodies were from Santa Cruz (Dallas, USA); anti-RFP tag (cat. No. A00682) antibody was from GenScript (Nanjing, China); anti-Insig1 (cat. No. ab70784), anti-Golgin-97 (cat. No. ab169287) and anti-SREBP-2 (cat. No … Get A Quote

摘要

SREBPs play important roles in the regulation of lipid metabolism, and are closely related to the occurrence and development of many metabolic diseases. Small molecular inhibitors of SERBPs are important tools in developing efficient treatment of metabolic diseases. However, there are no listing drug targeting SREBPs. Therefore, there is an urgent need to develop highly specific small molecules that inhibit SREBPs. In this study, using a hepatocyte-based high-throughput screening, we identified anhydroicaritin (AHI) as a novel inhibitor of SREBPs. HepG2, HL-7702, and human primary hepatocytes were used to verify the effects of AHI. We explored the mechanism by which AHI blocks the binding of SCAP/... More

关键词

25-Hydroxycholesterol (PubChem CID: 65094),3,5-Dihydroxy-4′-methoxy-6″,6″-dimethyl-4″,5″-dihydropyrano(2″,3″:7,8)-flavone (PubChem CID: 14583584),Anhydroicaritin,Anhydroicaritin (PubChem CID: 5318980),Compound C (PubChem CID: 11524144),Epimedin A (PubChem CID: 24721194),Epimedin B (PubChem CID: 5748393),Epimedin C (PubChem CID: 5748394),Hyperlipidemia,Icariin (PubChem CID: 5318997),Icarisid I (PubChem CID: 5745470),Icarisid II (PubChem CID: 5488822),Icaritin (PubChem CID: 14427423),Insulin resistance,Isoanhydroicaritin (PubChem CID: 5322079),Lovastatin (PubChem CID: 53232),MHY1485 (PubChem CID: 2834965),Obesity,Rapamycin (PubChem CID: 5284616),SR