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Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.

Front Cell Infect Microbiol. 2018; 
Hayashi Hideki,Kubo Yoshinao,Izumida Mai,Takahashi Etsuhisa,Kido Hiroshi,Sato Ko,Yamaya Mutsuo,Nishimura Hidekazu,Nakayama Kou,Matsuyama Toshi
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Recombinant Proteins was markedly released when the PRSS3 lysate was incubated with a purified EK (GenScript, #Z01003). Each Get A Quote

摘要

Cleavage and activation of hemagglutinin (HA) by trypsin-like proteases in influenza A virus (IAV) are essential prerequisites for its successful infection and spread. In host cells, some transmembrane serine proteases such as TMPRSS2, TMPRSS4 and HAT, along with plasmin in the bloodstream, have been reported to cleave the HA precursor (HA) molecule into its active forms, HA and HA. Some trypsinogens can also enhance IAV proliferation in some cell types (e.g., rat cardiomyoblasts). However, the precise activation mechanism for this process is unclear, because the expression level of the physiological activator of the trypsinogens, the TMPRSS15 enterokinase, is expected to be very low in such... More

关键词

enterokinase,genome structure and function,hemagglutinin processing,influenza A virus,transmembrane serine prot