黄金城集团

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes.

Nucleic Acids Res.. 2019-09; 
ZhangWeiyu,ChenFuquan,ChenRuiqing,XieDan,YangJiao,ZhaoXin,GuoRenpeng,ZhangYongwang,ShenYang,G?keJonathan,LiuLin,LuX
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis Nuclear extracts were precleared with Streptavidin MagBeads (GenScript, L00424) for 1 h. Get A Quote

摘要

Endogenous retroviruses (ERVs) contribute to ~10?percent of the mouse genome. They are often silenced in differentiated somatic cells but differentially expressed at various embryonic developmental stages. A minority of mouse embryonic stem cells (ESCs), like 2-cell cleavage embryos, highly express ERV MERVL. However, the role of ERVs and mechanism of their activation in these cells are still poorly understood. In this study, we investigated the regulation and function of the stage-specific expressed ERVs, with a particular focus on the totipotency marker MT2/MERVL. We show that the transcription factor Zscan4c functions as an activator of MT2/MERVL and 2-cell/4-cell embryo genes. Zinc finger domain... More

关键词