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Immunoproteasome is up-regulated in rotenone-induced Parkinson's disease rat model

Neurosci Lett. 2020; 
Congcong Sun, Guoyong Jia, Xingbang Wang, Yun Wang, Yiming Liu
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Molecular Biology Reagents … 2.5. Western blot. The SN of the brain tissues of the rats that were treated with various agents were mixed with the loading buffer (P0015, Beyotime, China), analyzed using 4%-20% SDS-PAGE (M42012C, GenScript, USA), and subjected to an immunoblot analysis … Get A Quote

摘要

The study was to investigate whether immunoproteasome (i-proteasome) and its downstream pathway are related to the pathogenesis of Parkinson's disease (PD). Rats were treated with rotenone showed significant weight loss and dyskinesia, which is consistent with the degeneration of TH-positive neurons and the activation of Iba-1-positive microglia/macrophages. Two major catalytic subunits of i-proteasome (PSMB9 and PSMB8) were seldom expressed in rat substantia nigra (SN) under normal condition, but they were significantly up-regulated with the release of TNF-α and IFN-γ after exposure to rotenone. In addition, compared with control group, the antigen presentation-related proteins antigen peptide transporter (T... More

关键词

Antigen presentation, Immunoproteasome, Parkinson’s disease, Rats, Rotenone, α-synuclein