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Claudin-4: Functional Studies Beyond the Tight Junction.

Methods Mol Biol.. 2011-07;  762:115-128
Eckelhoefer HA, Rajapaksa TE, Wang J, Hamer M, Appleby NC, Ling J, Lo DD. Division of Biomedical Sciences, University of California, Riverside, CA, USA
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摘要

Claudin-4 is an unusual member of the claudin family; in addition to its role in epithelial tight junction barrier function, it is a receptor for the Clostridium perfringens enterotoxin. We have also found that claudin-4 is regulated in mucosal epithelium M cells, both in increased expression of the protein and in redistribution into endocytosis vesicles. Our ongoing studies are studying the potential for developing ligands specific to claudin-4 for targeted delivery of cargo such as proteins and poly(DL-lactide-co-glycolide) nanoparticles to mucosal M cells. Methods for the study of claudin-4 movement within epithelial cells, and delivery of nanoparticles through targeted binding of claudin-4 are described.

关键词

Tight junction; Mucosal immunity; M cell; PLGA; Nanoparticles; Drug delivery; Vaccine