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Independently evolved viral effectors convergently suppress DELLA protein SLR1-mediated broad-spectrum antiviral immunity in rice

Nat Commun. 2022-11; 
Lulu Li , Hehong Zhang , Zihang Yang , Chen Wang , Shanshan Li , Chen Cao , Tongsong Yao , Zhongyan Wei , Yanjun Li , Jianping Chen , Zongtao Sun
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Catalog Antibody After washing, proteins retained on the beads were resolved by SDS-PAGE and probed with anti-GST (1:5000 dilution, Cat#A00130, Genscript) or anti-His (1:3000 dilution, ab18184, Abcam) antibody. Get A Quote

摘要

Plant viruses adopt diverse virulence strategies to inhibit host antiviral defense. However, general antiviral defense directly targeted by different types of plant viruses have rarely been studied. Here, we show that the single rice DELLA protein, SLENDER RICE 1 (SLR1), a master negative regulator in Gibberellin (GA) signaling pathway, is targeted by several different viral effectors for facilitating viral infection. Viral proteins encoded by different types of rice viruses all directly trigger the rapid degradation of SLR1 by promoting association with the GA receptor OsGID1. SLR1-mediated broad-spectrum resistance was subverted by these independently evolved viral proteins, which all interrupted the function... More

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