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Protein kinase C beta relieves autism-like behavior in EN2 knockout mice via upregulation of the FTO/PGC-1α/UCP1 axis

J Biochem Mol Toxicol. 2022-10; 
Xingyu Song, Qibo Hu, Xiaoheng Xu, Wei Pan
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摘要

Increasing evidence suggests that disruption of neuron activity contributes to the autistic phenotype. Thus, we aimed in this study to explore the role of protein kinase C beta (PKCβ) in the regulation of neuron activity in an autism model. The expression of PKCβ in the microarray data of autism animal models was obtained from the Gene Expression Omnibus database. Then, mice with autism-like behavior were prepared in EN2 knockout ( ) mice. The interaction between PKCβ on fat mass and obesity-associated protein (FTO) as well as between PGC-1α and uncoupling protein 1 (UCP1) were characterized. The effect of FTO on the N -methyladenosine (m6A) modification level of proliferator-activated receptor gamma coacti... More

关键词

EN2 knockout mice, N6-methyladenosine, autism, fat mass and obesity associated protein, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, protein kinase C beta, uncoupling protein 1