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Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks

BBRC. 2024-09; 
Li Chen , Minqing Liu , Yupeng Li , Yan Guan, Jiaqi Ruan , Zhilei Mao , Wenxiu Wang , Hong-Quan Yang , Tongtong Guo
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Catalog Antibody Prey and bait proteins were detected with anti-His antibody (GenScript, China, A00186), and Coomassie brilliant blue staining respectively. Get A Quote

摘要

Cryptochromes (CRYs) are blue light (BL) photoreceptors to regulate a variety of physiological processes including DNA double-strand break (DSB) repair. SUPPRESSOR OF GAMMA RADIATION 1 (SOG1) acts as the central transcription factor of DNA damage response (DDR) to induce the transcription of downstream genes, including DSB repair-related genes BRCA1 and RAD51. Whether CRYs regulate DSB repair by directly modulating SOG1 is unknown. Here, we demonstrate that CRYs physically interact with SOG1. Disruption of CRYs and SOG1 leads to increased sensitivity to DSBs and reduced DSB repair-related genes' expression under BL. Moreover, we found that CRY1 enhances SOG1's transcription activation of DSB repair-related gene... More

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