黄金城集团

目录产品 » Prime editor 2max

PEmax

PEmax is an improved version of PE2 with additional NLS and improved nCas9 domain, facilitating precise genome editing without the need for double-stranded DNA breaks. It significantly increases editing efficiency and accuracy compared to earlier systems and allows for a broader range of base conversions and edits within the genome design
RC00005
￥3500

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产品概述
Description PEmax is an improved version of PE2 with additional NLS and improved nCas9 domain, facilitating precise genome editing without the need for double-stranded DNA breaks. It significantly increases editing efficiency and accuracy compared to earlier systems and allows for a broader range of base conversions and edits within the genome design

应用指导
single guide RNA (sgRNA) dependent single-stranded DNA cleavage

技术背景
References 1. David R Liu, et al. “Enhanced prime editing systems by manipulating cellular determinants of editing outcomes”. Cell. 2021 Oct 28;184(22):5635-5652.e29. 2. David R Liu, et al. “Phage-assisted evolution and protein engineering yield compact, efficient prime editors”. Cell. 2023 Aug 31;186(18):3983-4002.e26.

质控参数
Purity ≥90% by SDS-PAGE, 86% by SEC-HPLC
Residual DNase Non-specific DNase activity
Endotoxin Level Control <10EU/mg

产品属性
Expression System Recombinant Cas9-based fusion with three NLS expressed by E.coli
Species S. pyogenes
Tag C-His tag
Molecular Weight 243.359KDa
Storage & Stability PEmax is supplied with storage buffer (50 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.5, at 25°C) and recommended to be stored at -80°C.

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