![PDGF-BB, Human (P. Pastoris-expressed) PDGF-BB, Human (P. Pastoris-expressed)](/product/documents/down?doc_name=Z02529_Activity.jpg&file=scm_files/productFile_notes/2018/04/17/191ffde9a492d10de4eb03423f34121b.jpg)
ED₅₀<3 ng/ml, measured by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells, corresponding to a specific activity of >3.3 x 10⁵ units/mg.
PDGF-BB, Human (P. pastoris-expressed)
Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. In vivo, PDGF-BB is mainly produced in heart and placenta, and predominantly expressed by osteoblasts, fibroblasts, smooth muscle cells, and glial cells. An inactive precursor of PDGF-BB is produced in the endoplasmic reticulum and then activated by a proprotein convertase after secretion. PDGF-BB functions in a paracrine manner and promotes organogenesis, human skeletal development, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. Therefore, PDGF-BB and its related pathways are potential pharmacological targets.
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Z02529 |
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¥760 |
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