![CTLA-4 Fc Chimera, Mouse CTLA-4 Fc Chimera, Mouse](/product/documents/down?doc_name=Z03391_activity.jpg&file=scm_files/productFile_notes/2021/05/24/42aefc79-13af-4db2-b316-1ffc6f6834c2.jpg)
Mouse B7-1/CD80 Protein, His Tag at 2 μg/ml (100 μl/well) can bind CTLA-4 Fc Chimera, Mouse with EC50=12.57 ng/ml when detected by M6 Goat Anti Mouse FC. Background was subtracted from data points before curve fitting.
CTLA-4 Fc Chimera, Mouse
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152, is an Inhibitory receptor acting as a major negative regulator of T-cell responses. CTLA-4 is a member of the immunoglobulin superfamily, which is expressed on the surface of T cells and transmits an inhibitory signal to T cells. CTLA-4 and CD28 are homologous receptors expressed by both CD4+ and CD8+ T cells, which mediate opposing functions in T-cell activation. Both receptors share a pair of ligands expressed on the surface of antigen-presenting cells (APCs). The affinity of CTLA-4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory co-receptor CD28.
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Z03391 |
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¥400 |
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