![SIRPα Fc Chimera, Human SIRPα Fc Chimera, Human](/product/documents/down?doc_name=Z03420_Activity.jpg&file=scm_files/productFile_notes/2018/04/17/6340ef07d8004f4212c3f3c58e316375.jpg)
Immobilized CD47, His, Human (Cat.No.Z03419) at 2 μg/mL (100 µl/well), can bind SIRPa Fc Chimera, Human with a linear range of 0.25-185 ng/mL.
SIRPα Fc Chimera, Human
Signal regulatory protein alpha (SIRPα, designated CD172a), is also known as CD172 antigen-like family member A (CD172a), also called SHPS-1 (SHP substrate 1) and previously, MyD-1 (Myeloid/Dendritic-1), which is a monomeric about 90kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily. SIRPα is Ubiquitous and highly expressed in brain. SIRPA/CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA/SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function by similarity. SIRPα recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production.
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Z03420 |
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¥2200 |
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