![CD27 Ligand/CD70 Fc Chimera, Human CD27 Ligand/CD70 Fc Chimera, Human](/product/documents/down?doc_name=Z03450_activity.jpg&file=scm_files/productFile_notes/2021/05/24/095db622-98b2-483e-9384-1ebd0e2031c0.jpg)
Immobilized CD27 (Mammalian,C-Fc-6His) at 1 µg/ml (100 μl/well) can bind CD27 Ligand/CD70 Chimera, Human with EC50=18.33 ng/ml when detected by SA-HRP. Background was subtracted from data points before curve fitting.
CD27 Ligand/CD70 Fc Chimera, Human
CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is a ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression.
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Z03450 |
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¥1760 |
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