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A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity

Sci Rep. 2024-02; 
Dareen Mikheil, Matthew A Larsen, Kevin Hsiao, Nathan H Murray, Tim Ugo, Hui Wang, Said A Goueli
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Catalog Peptides … We found the combination of an anti-cAMP primary antibody from GenScript (A01509) with a cAMP-SmBiT tracer containing a PEG3 linker between the cAMP and the SmBiT peptide … Get A Quote

摘要

3',5'-Cyclic adenosine monophosphate (cAMP), the first identified second messenger, is implicated in diverse cellular processes involving cellular metabolism, cell proliferation and differentiation, apoptosis, and gene expression. cAMP is synthesized by adenylyl cyclase (AC), which converts ATP to cAMP upon activation of G-protein coupled receptors (GPCRs) in most cases and hydrolyzed by cyclic nucleotide phosphodiesterases (PDEs) to 5'-AMP. Dysregulation of cAMP signaling is implicated in a wide range of pathophysiological conditions such as cardiovascular diseases, neurodegenerative and behavioral disorders, cancers, diabetes, obesity, cataracts, and others. Therefore, cAMP targeted therapies have been and ar... More

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