Figure 1. CP-55940-induced concentration-dependent stimulation of intracellular cAMP in CHO-K1/CNR2 cells. The EC50 of CP-55940 on this cell was 0.11 μM. Ratio = A660nm/B620nm x 104
CHO-K1/CB2 Stable Cell Line
The Cannabinoid receptor 2 (CNR2) is a Gi/o-coupled GPCR expressed in spleen, tonsils, bone marrow and peripheral blood leukocytes. There is one report that cannabinoid-induced inhibition of helper T cell activation is lost in macrophages obtained from CNR2 knockout mice. CNR2 is a potential therapeutic target in the treatment of various disease conditions, such as pain, multiple sclerosis, vascular disease, Parkinson's disease, and other central nerve system disorders.
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