| Species |
Gila monster |
| Protein Construction |
Exendin-4 (His48-Ser86)
Accession # P26349 |
|
| Purity |
> 96% as analyzed by SDS-PAGE
> 96% as analyzed by HPLC |
| Endotoxin Level |
< 0.2 EU/μg of protein by LAL method |
| Expression System |
E. coli |
| Theoretical Molecular Weight |
4.2 kDa |
| Application |
1. Regulates Glucose levels rapidly.
2. Reduces Insulin resistence.
3. Reduces Glucagon.
4. Reduces HbA1c.
5. Stimulates beta cell growth which stimulates insulin production. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4. |
| Reconstitution |
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage & Stability |
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes ß-cell proliferation and neogenesis in vitro and in animal models. |
| Synonyms |
Exendin-4 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
