![IFN-γ, Rat (CHO-expressed) IFN-γ, Rat (CHO-expressed)](/product/documents/down?doc_name=Z02982_Activity.jpg&file=scm_files/productFile_notes/2018/04/17/e07b842d95d87e28cc0c70d86c961ff0.jpg)
ED₅₀< 2.5 ng/ml, measured by cytotoxicity assay using WEHI-279 cells, corresponding to a specific activity of > 4×10⁵ units/mg.
IFN-γ, Rat (CHO-expressed)
Interferon-γ (IFN-γ), also known as Type II interferon or immune interferon, is a cytokine produced primarily by T-lymphocytes and natural killer cells. The active form of IFN-γ is an antiparallel dimer that interacts with the receptor IFN-γR1 and sets off IFN-γ/JAK/STAT pathway. IFN-γ signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-γ–induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-γ is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.
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Z02982 |
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¥200 |
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