![IL-12, Human(HEK 293-expressed) IL-12, Human(HEK 293-expressed)](/product/documents/down?doc_name=Z03023_Activity.jpg&file=scm_files/productFile_notes/2018/04/17/aa490b09b31a3eb73858f5eddf263e4f.jpg)
ED₅₀< 2 ng/ml, measured by the induction of IFN-γ from NK cells co-stimulated with IL-2, corresponding to a specific activity of > 5×10⁵ units/mg.
IL-12, Human(HEK 293-expressed)
Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human IL-6 receptor while the p35 subunit shows distant but significant sequence similarity to IL-6, G-CSF, and chicken MGF. These observations have led to the suggestion that IL-12 might have evolved from a cytokine/soluble receptor complex. Human and mouse IL-12 share 70% and 60% amino acid sequence homology in their p40 and p35 subunits, respectively. IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the mouse system.
Z03023 | |
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¥600 | |
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