![IL-22, Human IL-22, Human](/product/documents/down?doc_name=Z03243_induce IL-10 Secretion.png&file=scm_files/productFile_notes/2024/01/19/507d83c3-6422-4053-873d-918bebb5a72e.png)
Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The ED50 for this effect is less than 1.0 ng/ml.
![IL-22, Human IL-22, Human](/product/documents/down?doc_name=Z03243_SDS-PAGE.png&file=scm_files/productFile_notes/2024/01/19/c8099a2a-01b7-4dd5-8662-f99150d4f6ff.png)
Lane 1: 2 μg of IL-22, Human, reducing (R)
> 98% as analyzed by SDS-PAGE
IL-22, Human
Interleukin-22(IL-22) belongs to a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26) which are a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, such as IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens in epithelial cells such as those in the lung and gut. IL-22 along with IL-17 is produced by splenic LTi-like cells and Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
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Z03243 |
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¥700 |
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联系黄金城集团 |