![CD25/IL-2Rα Fc Chimera, Human CD25/IL-2Rα Fc Chimera, Human](/product/documents/down?doc_name=Z03400_Activity.jpg&file=scm_files/productFile_notes/2018/04/17/5f91fd235a9d3222a0e4aaa9f32bd7b5.jpg)
Immobilized IL-2,Human (Cat.No.Z03074) at 5μg/mL (100 μL/well) can bind CD25/IL-2Rα, Fc Chimera,Human with a linear range of 1.2-11 ng/mL.
CD25/IL-2Rα Fc Chimera, Human
The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2Rα, IL-2Rβ, and IL-2Rγ. The IL-2Rα is a type I transmembrane protein consisting of a 219 amino acid (a.a.) extracellular domain, a 19 a.a. transmembrane domain and a 13 a.a. intracellular domain, which is not involved in the transduction of IL-2 signal. Activated T cells, regulatory T cells (Tregs) and NK cells express high levels of CD25 and expression of the high-affinity IL-2Rα is mostly limited to these cell populations. Signaling via IL-2Rα mediates multiple biological processes in various cell populations, e.g. proliferation and differentiation of B cells and NK cells. A soluble form of IL-2Rα (IL-2Rα) appears in serum, concomitant with its increased expression on cells. The function of the soluble IL-2Rα is unclear. Increased levels of IL-2Rα in biological fluids reportedly correlate with increased T and B cell activation and immune system activation. Increased serum concentration of IL-2Rα has been observed in patients with a variety of inflammatory conditions and in the course of some leukemias and lymphomas.
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Z03400 |
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¥1200 |
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联系黄金城集团 |