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Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor.

Cell Microbiol.. 2015-06; 
Marion Avril, Maria Bernabeu, Vladimir Vigdorovich, Anjali Mascarenhas, Edwin Gomes, D. Noah Sather, Charles T. Esmon andJoseph D. Smith. Department of Global Health, University of Washington, Seattle, Washington, 98195, USA
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摘要

Cytoadhesion of Plasmodium falciparum-infected erythrocytes to endothelial protein C receptor (EPCR) is associated with severe malaria. It has been postulated that parasite binding could exacerbate microvascular coagulation and endothelial dysfunction in cerebral malaria by impairing the protein C-EPCR interaction, but the extent of binding inhibition has not been fully determined. Here we expressed the cysteine rich interdomain region (CIDRα1) domain from a variety of DC8 and DC13 P. falciparum erythrocyte membrane 1 (PfEMP1) proteins and show they interact in a distinct manner with EPCR resulting in weak, moderate, and strong inhibition of the APC-EPCR interaction. Overall, there was a positive correlat... More

关键词

Plasmodium falciparum; malaria; antigenic variation; adhesion