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A human Fab exclusively binding to the extracellular domain of LMP2A.

Biochem Biophys Res Commun.. 2016-11; 
Cao Q, Zhang D, Mao Y, Meng C, Zhu J, Feng Z, Chen R. Department of Otolaryngology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
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摘要

In the areas of North Africa, Southeast Asia as well as South China, Nasopharyngeal carcinoma (NPC) is among the most widespread cancers. Plenty of research findings confirmed that Epstein-Barr virus (EBV) played a crucial role in NPC. EBV-encoded Latent membrane protein 2A (LMP2A) which continuously expressed in cell membrane protein induced an epithelial-mesenchymal transition and increased the number of side population stem-like cancer cells in NPC. This reveals that LMP2A could contribute to the development and recurrence in NPC. Above evidences suggest that LMP2A could be the potential target molecule in the treatment of NPC. In the current study, a novel human antibody Fab (Fab29) against the extracellula... More

关键词

G2/Antibody; EBV; LMP2A; NPCM arrest; GDF9; NOBOX; homozygous truncating variant; primary ovarian insufficiency