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Monomeric C‐reactive protein and inflammation in Age‐related Macular Degeneration The role of monomeric C‐reactive protein in AMD.

J Pathol.. 2016-10; 
Chirco KR,Whitmore SS,Wang K,Potempa LA,Halder JA,Stone EM,Tucker BA,Mullins RF.
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... was further modified using a reverse acylation procedure to enhance aqueous solubility [27] [26]. Based on testing using the ToxinSensorTM Gel Clot Endotoxin Assay Kit (GenScript; cat# L00351; Piscataway, NJ), 20µg/mL of mCRP contains < 0.125 EU/mL (~0.025 ng/mL) ...

摘要

Age-related macular degeneration (AMD) is a devastating disease characterized by central vision loss in elderly individuals. Previous studies have suggested a link between elevated levels of total C-reactive protein (CRP) in the choroid, CFH genotype, and AMD status; however, the structural form of CRP present in the choroid, its relationship to CFH genotype, and its functional consequences have not been assessed. In this report, we studied genotyped human donor eyes (n = 60) and found that eyes homozygous for the high-risk CFH (Y402H) allele had elevated monomeric CRP (mCRP) within the choriocapillaris and Bruch's membrane, compared to those with the low-risk genotype. Treatment of choroidal endothelial cells ... More

关键词

C-reactive protein; ICAM-1; age-related macular degeneration; choroid; inflammation; microvasculature