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Endoplasmic reticulum protein ERp46 in prostate adenocarcinoma.

Oncol Lett.. 2017-05; 
Duivenvoorden WCM,Hopmans SN,Austin RC,Pinthus JH.
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... Signaling Technology, Inc., Danvers, MA, USA). Equal protein loading was verified using mouse β‑actin‑specific antibody (A00702; dilution, 1;1,000; GenScript, Piscataway, NJ, USA). Secondary horse- radish peroxidase‑conjugated …

摘要

Endoplasmic reticulum (ER) protein ERp46 is a member of the protein disulfide isomerase family of oxidoreductases, which facilitates the reduction of disulfides in proteins and their folding. Accumulation of misfolded proteins has been implicated in cancer. The objectives of the present study were to investigate the role of ERp46 in prostate cancer, its expression and its effects on prostate cancer growth. A tissue microarray with human prostate cancer and normal prostate tissue samples was stained for ERp46 followed by image analysis. Human prostate adenocarcinoma 22Rv1 cells were stably transfected with short hairpin RNA (shRNA) specific for ERp46, a non-effective scrambled control or a plasmid containing ful... More

关键词

endoplasmic reticulum stress; prostate carcinoma; protein disulfide isomerase; thioredoxin