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Lactobacillus salivarius reverse diabetes-induced intestinal defense impairment in mice through non-defensin protein.

J Nutr Biochem.. 2016-09; 
Chung PH, Wu YY, Chen PH, Fung CP, Hsu CM, Chen LW.
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... ampicillin (100 μg/ml). 2.9. Endotoxin Levels in Portal Vein. The portal plasma endotoxin levels were determined using the ToxinSensorTM Chromogenic LAL Endotoxin Assay Kit (GenScript, Cat. No. L00350). The blood samples ...

摘要

Altered intestinal microbiota and subsequent endotoxemia play pathogenic roles in diabetes. We aimed to study the mechanisms of intestinal defense impairment in type 1 diabetes and the effects of Lactobacillus salivarius as well as fructooligosaccharides (FOS) supplementation on diabetes-induced bacterial translocation. Alterations in the enteric microbiome, expression of mucosal antibacterial proteins and bacteria-killing activity of the intestinal mucosa in streptozotocin (STZ)-induced diabetic mice and Ins2(Akita) mice were investigated. The effects of dead L. salivarius (2×10(8)CFU/ml) and FOS (250 mg per day) supplementation for 1 week on endotoxin levels and Klebsiella pneumoniae translocation were also ... More

关键词

Endotoxin; Enteric dysbiosis; Fructooligosaccharides; Hyperglycemia; K. pneumoniae; Reg3β