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RBFOX3 Promotes Tumor Growth and Progression via hTERT Signaling and Predicts a Poor Prognosis in Hepatocellular Carcinoma.

Theranostics.. 2017-07; 
Liu T, Li W, Lu W, Chen M, Luo M3, Zhang C, Li Y, Qin G, Shi D, Xiao B, Qiu H, Yu W4, Kang L4, Kang T, Huang W,5, Yu X3, Wu X, Deng W.
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... To further study whether RBFOX3 bound to the hTERT promoter directly, protein extracts prepared from flag-RBFOX3 overexpressing Hep3B and HepG2 cells were purified with GenScript Anti-DYKDDDDK G1 Affinity Resin (Cat. No. L00432). ...

摘要

Activation of the telomere maintenance mechanism is a key hallmark of cancer. Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase, which is highly expressed in more than 80% of tumors, including hepatocellular carcinoma (HCC). However, the exact mechanisms by which hTERT is up-regulated in HCCs and promotes tumor growth and progression is not fully understood. The aim of this study was to discover the novel molecular targets that modulate hTERT signaling and HCC growth. In this study, we pulled down and identified RBFOX3 (RNA binding protein fox-1 homolog 3) as a novel hTERT promoter-binding protein in HCC cells using biotin-streptavidin-agarose pull-down and proteomics approac... More

关键词

HCC; promoter-binding protein.; telomerase reverse transcriptase