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Protein Nanoparticles Made of Recombinant Viral Antigens: A Promising Biomaterial for Oral Delivery of Fish Prophylactics.

Front Immunol. 2018; 
Thwaite Rosemary,Ji Jie,Torrealba Débora,Coll Julio,Sabés Manel,Villaverde Antonio,Roher N
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Proteins, Expression, Isolation and Analysis … Protein was quantified by western blot using an anti-His-tag antibody (Genscript A00186-100), and the protein concentration was calculated from a standard curve using recombinant protein and Quantity One software (Bio-Rad) … Get A Quote

摘要

In the search for an eminently practical strategy to develop immunostimulants and vaccines for farmed fish, we have devised recombinant viral antigens presented as "nanopellets" (NPs). These are inclusion bodies of fish viral antigenic proteins produced in . Soluble recombinant proteins are too labile to endure the environment and maintain full functionality, and therefore require encapsulation strategies. Yet when they are produced as nanostructures, they can withstand the wide range of gastrointestinal pH found in fish, high temperatures, and lyophilization. Moreover, these nanomaterials are biologically active, non-toxic to fish, cost-effective regarding production and suitable for oral admi... More

关键词

bacterial inclusion bodies,fish,oral vaccines,protein nanoparticles,viral anti