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Convergence of PASTA kinase and two-component signaling in response to cell wall stress in .

J. Bacteriol.. 2018-04; 
KelloggStephanie L,KristichChristoph
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… CroR. Membranes were blocked with 5% milk in TBS. CroS was detected using antibodies to epitope tags 376 used in this study: a polyclonal rabbit anti-strep antibody (GenScript Cat. # A00626) or a polyclonal 377 rabbit anti-HA antibody (Invitrogen Cat …

摘要

Two common signal transduction mechanisms used by bacteria to sense and respond to changing environments are two-component systems (TCSs) and eukaryotic-like Ser/Thr kinases and phosphatases (eSTK/Ps). is a Gram-positive bacterium and serious opportunistic pathogen that relies on both a TCS and an eSTK/P pathway for intrinsic resistance to cell wall-targeting antibiotics. The TCS consists of a histidine kinase (CroS) and response regulator (CroR) that become activated upon exposure of cells to cell wall-targeting antibiotics, leading to modulation of gene expression. The eSTK/P pathway consists of a transmembrane kinase (IreK) and its cognate phosphatase (IreP), which act antagonistically to mediate antibi... More

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