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Effect of GDNF on Morphology, Proliferation, and Phagocytic Activity of Rat Neonatal Cortex Isolated Microglia

BioNanoSci. 2016-01; 
Margarita Zhuravleva & Albert Rizvanov1 & Yana Mukhamedshina
Products/Services Used Details Operation
MOG 35-55 (myelin oligodendrocyte glycoprotein) and βAP 25-35 (β-amyloid peptide) were obtained from GenScript (USA), #RP10245 and RP10008-5, respectively

摘要

t Microglia are the main defenders of the central nervous system and at the same time are involved in the pathogenesis of various neurological disorders. Microglia hyperactivity or phagocytic impairment exacerbates degenerative processes in nervous tissue leading to further loss of function. A variety of factors and cytokines may modify microglia function. In our study, it was shown that glial cell line-derived neurotrophic factor (GDNF), a well-known neuroprotective molecule, decreases phagocytic activity of microglia in vitro model of spinal cord injury. Recombinant adenovirus encoding GDNF (Ad5-GDNF) transfected microglia have shown the same effect and can be potentially used as a therapeutic agen... More

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