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HSP90 Inhibition and Cellular Stress Elicits Phenotypic Plasticity in Hematopoietic Differentiation

Cell Reprogram. 2017-10; 
LawagAbdalla A, NapperJennifer M, HunterCaroline A, BaconNickolas A, DeskinsSeth, El-HamdaniManaf, GovenderSarah-Leigh, KocEmine C, SollarsVince
Products/Services Used Details Operation
… Assays performed using recombinant stem cell factor (SCF) used either 50 ng/mL (standard) or 25 ng/mL (phase 1 medium) of recombinant murine SCF produced in Pichia pastoris, purchased from GenScript (Catalog # Z02997-50) …

摘要

Cancer cells exist in a state of Darwinian selection using mechanisms that produce changes in gene expression through genetic and epigenetic alteration to facilitate their survival. Cellular plasticity, or the ability to alter cellular phenotype, can assist in survival of premalignant cells as they progress to full malignancy by providing another mechanism of adaptation. The connection between cellular stress and the progression of cancer has been established, although the details of the mechanisms have yet to be fully elucidated. The molecular chaperone HSP90 is often upregulated in cancers as they progress, presumably to allow cancer cells to deal with misfolded proteins and cellular stress associated... More

关键词

HSP90,cell plasticity,cellular stress,epigenetics,molecular evolution,stem c