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Pertussis toxin targets the innate immunity through DAP12, FcRγ, and MyD88 adaptor proteins

Immunobiology. 2017-04; 
PhongsisayVongsavanh, IizasaEi'ichi, HaraHiromitsu, YoshidaHi
Products/Services Used Details Operation
… Pertussis toxin (product no. 180) was purchased from List Biological laboratories, INC. LPS (L4516) was from Sigma. Pam3 CSK4 (2201) was from IMGENEX. ToxinSensor™ chromogenic LAL endotoxin assay kit (L00350) was purchased from Genscript. 2.2. Binding assays …

摘要

Activation of the innate immunity by adjuvants, such as pertussis toxin (PTX), in the presence of autoreactive lymphocytes and antigen mimicry is sufficient to trigger autoimmunity. Toll-like, C-type lectin, and immunglobulin-like receptors play an important role in the innate immunity by sensing a variety of microbial products through several adaptor proteins, including MyD88, DAP12, and FcRγ. This study investigated the interaction between PTX and innate immune components. The direct interactions between coated PTX and receptor-fusion proteins were examined using ELISA-based binding assays. Functionally, PTX-binding receptors could be classified into two groups: inhibition (DAP12-coupled TREM... More

关键词

Adjuvant,Autoimmunity,Innate immunity,Pertussis toxin,Rece