资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Generation of antibody-based therapeutics targeting the Idiotype of B-cell Malignancies.

Antib Ther. 2019-01;

WeissEmily, SarnovskyRobert, HoMitchell, AronsEvgeny, KreitmanRobert, AngelusEvan, AntignaniAntonella, FitzGeraldD

Products/Services Used	Details	Operation
	… by DNA synthesis (Blue Heron Biotech), and include an OmpA periplasm directing signal sequence (cleaved upon entry in the periplasm), followed by a FLAG tag epitope (DYKDDDDK) to allow binding to an anti-FLAG affinity purification resin (Genscript catalog #L00432), the …

摘要

A feature of many B-cell tumors is a surface-expressed immunoglobulin (sIg). The complementarity determiningregions (CDRs)of the sIg， termed the 'idiotype'， are unique to each tumor. We report on a phage selection strategy to generate anti-idiotype therapeutics that react with sIg CDR3 sequences: the MEC1 B-cell tumor line was used as proof of concept.