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Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis.

Int. J. Biol. Sci.. 2019; 
FengHao,ZhaoXin,GuoQiqiang,FengYanling,MaMengtao,GuoWendong,DongXiang,DengChengsi,LiChunlu,SongXiaoyu,HanShuai,Ca
Products/Services Used Details Operation
… 509 Biotechnology, Inc. (Dallas, TX, USA). Mouse anti-c-Myc-tag (A00704) was purchased from Genscript (Piscataway, NJ). Rabbit anti-MMP-2 (10373-2-ap) and rabbit anti-MMP-9 (10375-2-ap) were purchased from Proteintech Group, Inc. (Rosemont, IL, USA) …

摘要

Proliferative vitreoretinopathy (PVR) is the most serious fibrous complication that causes vision loss after intraocular surgery, and there is currently no effective treatment in clinical. Autophagy is an important cell biological mechanism in maintaining the homeostasis of tissues and cells, resisting the process of EMT. However, it is still unclear whether autophagy could resist intraocular fibrosis and prevent PVR progression. In this study, we investigated the expression of mesenchymal biomarkers in autophagy deficiency cells and found these proteins were increased. The mesenchymal protein transcription factor Twist can bind to autophagy related protein p62 and promote the degradation of Twist, wh... More

关键词

Atg7,Autophagy,EMT,Proliferative vitreoretinopathy,Retinal pigment epithelial,T