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Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice.

Neuropharmacology. 2019; 
CrowleyNicole A,MageeSarah N,FengMengyang,JeffersonSarah J,MorrisChristian J,DaoNigel C,BrockwayDakota F,LuscherBern
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… For quantitation, the corresponding protein bands were normalized to β-actin quantitated in blots of total mPFC lysates of these same samples, using mouse anti-β- actin (1:5000, A00702, Genscript. Piscataway, NE, USA)(Kilpatrick et al 2016) …

摘要

Ketamine is a fast acting experimental antidepressant with significant therapeutic potential for emotional disorders such as major depressive disorder and alcohol use disorders. Of particular interest is binge alcohol use, which during intermittent withdrawal from drinking involves depressive-like symptoms reminiscent of major depressive disorder. Binge drinking has been successfully modeled in mice with the Drinking in the Dark (DID) paradigm, which involves daily access to 20% ethanol, for a limited duration and selectively during the dark phase of the circadian light cycle. Here we demonstrate that DID exposure reduces the cell surface expression of NMDA- and AMPA-type glutamate receptors in the prelim... More

关键词

Alcohol,Drinking in the dark,Ketamine,Prelimbic co