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Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster.

Neurosci. Lett.. 2019; 
XiaoChengfeng,QiuSh
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… (2) repo-Gal4/UAS-hsp70-myc flies: primary antibody, rabbit anti-c-myc (A00173, GenScript) at 1:50 … Science Foundation of Jiangsu Province (BK20180497 to SQ), a grant for Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse of Nanjing University of …

摘要

Drosophila egg-derived tyrosine phosphatase (EDTP) is a lipid phosphatase essential for oogenesis and muscle function. Loss-of-EDTP is lethal at early developmental stages. Hypomorphic mutation of EDTP causes impaired muscle performance and shortened lifespan. Mutation of MTMR14, a mammalian homolog to EDTP, is associated with muscle fatigue in rodents and a rare genetic disease called centronuclear myopathy in humans. Despite the deleterious consequences, downregulation of MTMR14 promotes autophagy. It is proposed that selective downregulation of EDTP/MTMR14 in non-muscle tissues improves the survivorship to cellular wastes and extends lifespan. Here, we show that downregulation of EDTP in glial cells ... More

关键词

Autophagy,Drosophila melanogaster,Egg-derived tyrosine phosphatase (EDTP),Glial cell,Polyglutamine protein aggreg