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Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity.

FASEB J.. 2015-06; 
HwangInjae,ParkYoon Jeong,KimYeon-Ran,KimYo Na,KaSojeong,LeeHo Young,SeongJe Kyung,SeokYeong-Jae,KimJae
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Proteins, Expression, Isolation and Analysis … Serum insulin, endotoxin, TNF-α, and cholesterol were measured using a mouse insulin ELISA kit (AKRIN-011T; Shibayagi, Gunma Pref, Japan), ToxinSensor Chromogenic Endotoxin Assay Kit (L00350; Genscript, Piscataway, NJ, USA), mouse TNF-α detection kit (KMC3011 … Get A Quote

摘要

Firmicutes and Bacteroidetes, 2 major phyla of gut microbiota, are involved in lipid and bile acid metabolism to maintain systemic energy homeostasis in host. Recently, accumulating evidence has suggested that dietary changes promptly induce the alteration of abundance of both Firmicutes and Bacteroidetes in obesity and its related metabolic diseases. Nevertheless, the metabolic roles of Firmicutes and Bacteroidetes on such disease states remain unclear. The aim of this study was to determine the effects of antibiotic-induced depletion of Firmicutes and Bacteroidetes on dysregulation of energy homeostasis in obesity. Treatment of C57BL/6J mice with the antibiotics (vancomycin [V] and bacitracin [B]), ... More

关键词

gut hormone,insulin sensitivity,metabol