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IL-15 Mediates Mitochondrial Activity through a PPAR-Dependent-PPAR-Independent Mechanism in Skeletal Muscle Cells.

PPAR Res. 2016-01; 
ThorntonShantaé M,KroloppJames E,AbbottMarc
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Biochemicals … serum (#H1270), and insulin (#I9278). Recombinant IL-15 was from GenScript (#Z03309-50) and GW-6471 (#11697) and GSK-3787 (#15219) were obtained from Cayman Chemicals. Trizol (#15596), SYBR green (#A25742 … Get A Quote

摘要

Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed "myokines," has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPAR and/or PPAR as targets of IL-15 signaling. C2C12 SKM cells were differentiated for 6 days and treated every other day with IL-15 (100 ng/mL), a PPAR inhibitor (GW-6471), a PPAR inhibitor (GSK-3787), or both IL-15 and the i... More

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